Investigating tumor perfusion by hyperpolarized (thirteen) C MRI with comparison to traditional gadolinium distinction-enhanced MRI and pathology in orthotopic human GBM xenografts.

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We utilised a transmission grating (TG) like a dispersive element inside our stretcher and compressor. A compact configuration was adopted, where by the stretcher as well as compressor shared one particular grating similar to that in Ref.

Determine 7 exhibits the calculated dispersion payment end result. The compressed pulse period is close to 185 fs when the duration of enter pulses is a hundred and fifty fs. The discrepancy involving them will probably be noticeably lessened with an extended pulse enter simply because uncompensated high-buy dispersion issues less for longer pulses. This configuration was used to exhibit the compressibility of our amplified pulses at the preliminary stage of our total technique. In the future we would adopt a grating-pair compressor for fantastic compensation for top-buy dispersion.

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]. Etalon insertion would cause further loss, even so, time-to-time optimization would introduce the risk of ingredient problems and instability for the program. A nonlinear regenerative amplifier could straight produce pulses having a period as low as ninety seven fs as well as a spectral bandwidth of 19 nm[

Many procedures are actually adopted to solve this problem. An acousto-optical programmable dispersive filter could be utilized to modulate the seed’s spectrum to suppress the achieve-narrowing outcome[

The blended gain is intricate and will be measured under various pumping circumstances due to quasi-a few-stage method habits in the Yb-doped acquire medium. The blueshift, with 1 peak from 1037 nm under the same crystal placement orientation to 1035 nm beneath the orthogonal crystal placement orientation, could consequence with the reabsorption losses at a protracted wavelength while in the crystal where by the laser polarization is parallel to its Nm -axis, making the attain at 1035 nm larger than that at 1037 nm below orthogonal orientation.

Even though BGO and LT produced the narrowest SC spectra (a bit less than 1.five optical octaves), they could be seen as extremely desirable nonlinear components for broadband SC technology with pumping at for a longer period laser wavelengths. Owing to its massive nonlinearity, BGO exhibited the lowest SC generation threshold (seventy eight nJ) Among the many investigated elements, that's 25 % decreased than in KGW and will be considered as excellent nonlinear substance for quite small-threshold SC generation. The observed steady and sturdy injury-cost-free effectiveness of BGO and GGG at 200 kHz pulse repetition price indicates that these nonlinear materials have a potential for SC era at even increased, MHz, repetition rates. What's more, these supplies deliver SC radiation with a wonderful set of parameters which have been essential for apps in higher pace spectroscopy and imaging that employ bulk-produced SC, see e.g.17,18,19,20.

We formulated a diode-pumped Yb:KGW regenerative amplifier as the entrance end in the kilohertz terawatt laser procedure. Broad bandwidth pulses have been received by applying twin crystals with distinctive orientations in their optical axes[

相关工作得到了上海扬帆计划、国家重点研发计划、中国科学院战略性先导科技专项、国家自然科学基金项目、上海市优秀学术/技术带头人计划、上海市市级科技重大专项、中国科学院青年创新促进会的支持。（强场激光物理国家重点实验室供稿）

-switched laser output underneath the two crystal placement configurations. The black line denotes the configuration with the crystals positioned in the exact same orientation, while the crimson line is beneath the configuration of crystals placed in more info orthogonal orientation.

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]. The dual-crystal configuration lowers the thermal load on each crystal whilst preserving a significant acquire, and facilitates the compensation of every one’s thermal lensing result. Thus, the laser cavity can get the job done with a considerable balance vary in excess of the thermal lensing influence variation.